Will return a normalization matrix.
getNormalizationMatrix( umi4c, norm_bins = 10^(3:6), post_smooth_win = 50, r_expand = 1.2 )
umi4c | |
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norm_bins | Numeric vector with the genomic bins to use for normalization. Default: 1K, 10K, 100K, 1Mb. |
post_smooth_win | Numeric indicating the smoothing window to use. Default: 50. |
r_expand | Numeric indicanting the expansion value for normalization. Default: 1.2. |
Creates a matrix of normalization factors using as a reference the profile specified in the UMI4C object.